Antileprotic Drugs: Mechanism of Action

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Anti-Leprotic Drug

Leprosy is infectious disease caused by mycobacterium leprae. Leprosy result in sever nerve damage, loose skin, and muscle wasting.

Anti-leprotic use against mycobacterial leprae to treat leprosy.


List of antileprotic drugs are,

  • Sulfameter
  • Rifampicin
  • Ethionamide
  • Acedapson
  • Dapsone
  • Thalidomide
  • Clarithromycin
  • Clofazimine


Mechanism of action

It block synthesis of DNA gyrase which block chromosomal coil formation. It also inhibits the peptide formation essential for amino acid chain formation. Antileprotic drug block both actions to stop the multiplication of bacteria and genetic death of bacteria occur.  


Side-Effects 

Antileprotic drug side effects are nausea, dehydration, skin rashes, fever, taste disorder and disturbing behavior. 

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